PROTAC BTK Degrader-2
Product Specifications
UNSPSC Description
PROTAC BTK Degrader-2 is a potent BTK PROTAC degrader. PROTAC BTK Degrader-2 effectively reduces BTK protein levels[1].
Target Antigen
Btk; PROTACs
Type
Reference compound
Related Pathways
PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/protac-btk-degrader-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C[C@H](N2N=C(C3=CC=C(OC4=CC=C(F)C=C4F)C=C3)C(C(N)=O)=C2N)CCC1)OCCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O
Molecular Weight
976.97
References & Citations
[1]Zorba A, et, al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122828/PROTAC-BTK-Degrader-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122828/
Clinical Information
No Development Reported
CAS Number
2250382-66-0
Curated Selection
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