DB818
DB818 is a potent inhibitor of Homeobox A9 (HOXA9) . HOXA9 is a transcription factor regulating haematopoiesis and leukaemia cell proliferation, involving in acute myeloid leukaemia (AML) . DB818 inhibits AML cell lines growth, induces apoptosis[1].
Product Specifications
CAS Number
[790241-43-9]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db818.html
Purity
98.36
Solubility
H2O : 4 mg/mL (ultrasonic)
Smiles
N=C(C1=CC=C(C2=CC=C(C3=NC4=CC=C(C(N)=N)C=C4N3)S2)C=C1)N
Molecular Formula
C19H16N6S
Molecular Weight
360.44
References & Citations
[1]Sonoda Y, et al. Effects of HOXA9 Inhibitor DB818 on the Growth of Acute Myeloid Leukaemia Cells. Anticancer Res. 2021 Apr;41 (4) :1841-1847.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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