Pyrazofurin

Pyrazofurin is an antitumor pyrimidine nucleoside analogue and a orotate-phosphoribosyltransferase inhibitor. Pyrazofurin inhibits cell proliferation and intracellular DNA synthesis by inhibiting uridine 5'-phosphate synthase. Pyrazofurin is also an antibiotic with a broad spectrum of antiviral activity[1][2][3][4].

Product Specifications

CAS Number

[30868-30-5]

Product Name Alternative

Pirazofurin

UNSPSC

12352005

Target

Antibiotic; DNA/RNA Synthesis; HIV; Influenza Virus; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/pyrazofurin.html

Purity

98.18

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N)C1=NNC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=C1O

Molecular Formula

C9H13N3O6

Molecular Weight

259.22

References & Citations

[1]Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6 (1) :19-27.|[2]Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37 (6) :329-339.|[3]Petrie CR 3rd, et al. Synthesis and biological activity of certain nucleoside and nucleotide derivatives of pyrazofurin. J Med Chem. 1986 Feb;29 (2) :268-78. |[4]Canonico PG, et al. Antiviral efficacy of pyrazofurin against selected RNA viruses. Antiviral Res. 1982 Dec;2 (6) :331-7.