β-Rubromycin

β-Rubromycin, a quinone antibacterial agent, is a selective HIV-1 reverse transcriptase inhibitor with a Ki of 0.27 μM. β-Rubromycin is a potent telomerase inhibitor with an IC50 of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC50 values of 19.5 µM and 22.7 µM, respectively[1][2].

Product Specifications

CAS Number

[27267-70-5]

UNSPSC

12352005

Hazard Statement

H302+H312-H319-H351

Target

Bacterial; HIV; Reverse Transcriptase; Telomerase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/β-rubromycin.html

Purity

97.7

Solubility

DMSO : 1 mg/mL (ultrasonic; warming)

Smiles

O=C(C(O1)=CC(C=C(CC[C@@]2(OC(C3=O)=C(C(C4=C3C(O)=C(OC)C=C4OC)=O)C2)O5)C5=C6O)=C6C1=O)OC

Molecular Formula

C27H20O12

Molecular Weight

536.44

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P405-P501

References & Citations

[1]Goldman ME, et al. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site. Mol Pharmacol. 1990;38 (1) :20-25.|[2]Ueno T, et al. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry. 2000 May 23;39 (20) :5995-6002.