PF-00217830
Product Specifications
UNSPSC Description
F-00217830 is an agonist ofDopamine D2 receptor. PF-00217830 inhibits of spontaneous locomotor activity and 2,5-dimethoxy-4-iodoamphetamine-induced head twitches in rats[1].
Target Antigen
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-00217830.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C2NC(OCCCCN3CCN(CC3)C4=C5C=CC=CC5=CC=C4)=CC=C2CC1
Molecular Weight
430.54
References & Citations
[1]Johnson DS, et al. Discovery of PF-00217830: aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder. Bioorg Med Chem Lett. 2011;21(9):2621-2625.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121775/PF-00217830-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121775/
Clinical Information
Phase 2
CAS Number
846032-02-8
Curated Selection
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