AZ1729

AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator, acting as a direct allosteric agonist and as a positive allosteric modulator. AZ1729 increases the activity of the endogenously produced short chain fatty acid propionate in Gi-mediated pathways, but not at those transduced by Gq/G11. AZ1729 induces inhibition of isoproterenol-induced lipolysis in mouse adipocytes. AZ1729 also can Induce migration of human neutrophils. AZ1729 can be used for researching the signaling pathways of the physiological roles of FFA2[1].

Product Specifications

CAS Number

[2016864-46-1]

UNSPSC

12352005

Target

Free Fatty Acid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/az1729.html

Purity

99.8

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC(C2=C(C)N=C(NC(N)=N)S2)=C1)C3=CC=C(F)C=C3

Molecular Formula

C18H16FN5OS

Molecular Weight

369.42

References & Citations

[1]Bolognini D, Moss CE, Nilsson K, et al. A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias. J Biol Chem. 2016;291 (36) :18915-18931.