Bunitrolol

Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research[1][2][3].

Product Specifications

CAS Number

[34915-68-9]

Product Name Alternative

KO 1366

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bunitrolol.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

N#CC1=CC=CC=C1OCC(CNC(C)(C)C)O

Molecular Formula

C14H20N2O2

Molecular Weight

248.32

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Tsuchihashi H, et al. Effects of bunitrolol on adrenergic and serotonergic receptors. Jpn J Pharmacol. 1987 Nov;45 (3) :349-56. |[2]Hasegawa Y, et al. Chronic effects of bunitrolol and pindolol on blood pressure, heart rate, vascular lesions, and plasma renin activity in hypertensive rats. Jpn J Pharmacol. 1982 Aug;32 (4) :742-5.|[3]Van Petten G R, et al. Chronic preparation of the pregnant ewe and fetus for pharmacological research: the placental transfer and fetal effects of bunitrolol. Journal of Pharmacological Methods, 1978, 1 (1) : 45-60.