Sp-8-CPT-cAMPS

Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II) . Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold[1][2].

Product Specifications

CAS Number

[129693-13-6]

UNSPSC

12352005

Target

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sp-8-cpt-camps.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@]2(S)=O)([H])N3C4=NC=NC(N)=C4N=C3SC(C=C5)=CC=C5Cl

Molecular Formula

C16H15ClN5O5PS2

Molecular Weight

487.88

References & Citations

[1]Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265 (18) :10484-91.|[2]Boese M, et, al. Effect of cyclic GMP-dependent vasodilators on the expression of inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP. Br J Pharmacol. 1996 Oct;119 (4) :707-15.|[3]Spicuzza L, et, al. Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol. 2001 Aug;133 (8) :1201-12.