SAK3
Product Specifications
UNSPSC Description
SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity[2].
Target Antigen
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sak3.html
Purity
99.44
Solubility
DMSO : 2 mg/mL (ultrasonic;warming)
Smiles
O=C(OCC)C1=C(C2(CC1=O)N3C=CC=C(C3=NC2=O)C)N4CCCCC4
Molecular Weight
369.41
References & Citations
[1]Yasushi Yabuki, et al. Pharmacological properties of SAK3, a novel T-type voltage-gated Ca<sup>2+</sup> channel enhancer. Neuropharmacology. 2017 May 1;117:1-13.|[2]Jing Xu, et al.T-Type Ca<sup>2+</sup> Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model. Int J Mol Sci. 2021 Jun 8;22(12):6185.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120597/SAK3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120597/SAK3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1256269-87-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
