AZD8542
Product Specifications
UNSPSC Description
AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is a Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment[1][2].
Target Antigen
Hedgehog; Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/azd8542.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)OCC2=NC=CC=C2)NC3=CC(C4=CN(C)C=N4)=C(C)C=C3C
Molecular Weight
412.48
References & Citations
[1]Rosa F. Hwang, INHIBITION OF THE HEDGEHOG PATHWAY TARGETS THE TUMOR-ASSOCIATED STROMA IN PANCREATIC CANCER. Mol Cancer Res. 2012 Sep; 10(9): 1147–1157.|[2]Dakin Leslie, et al. Preparation of amide compounds containing heterocycle moiety as hedgehog pathway inhibitors. World Intellectual Property Organization, WO2009027746 A1
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120499/AZD8542-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120499/
Clinical Information
No Development Reported
CAS Number
1126366-36-6
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