Reticulol

Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].

Product Specifications

CAS Number

[26246-41-3]

Product Name Alternative

K 251-1

UNSPSC

12352005

Hazard Statement

H302+H312-H319

Target

Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/reticulol.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(O)C(OC)=C(O)C=C2C=C(C)O1

Molecular Formula

C11H10O5

Molecular Weight

222.19

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo) . 1975 Jul;28 (7) :558-60. |[2]Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49 (3) :146-53. |[3]Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo) . 1975 Jul;28 (7) :558-60.