Inotodiol

Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active[1][2][3][4][5].

Product Specifications

CAS Number

[35963-37-2]

UNSPSC

12352211

Target

Apoptosis; Caspase; MDM-2/p53; MMP; NF-κB; p38 MAPK; SOD; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/inotodiol.html

Purity

98.29

Solubility

10 mM in DMSO

Smiles

C[C@@]1(CC[C@@H]2O)C(CC[C@@]34C)=C(CC[C@@]1([H])C2(C)C)[C@@]3(CC[C@]4([H])[C@H](C)[C@H](O)C/C=C(C)\C)C

Molecular Formula

C30H50O2

Molecular Weight

442.72

References & Citations

[1]Nakata T, et al. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem. 2007;15 (1) :257-264.|[2]Zhang SD, et al., Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. Phytomedicine. 2019 Jul;60:152957.|[3]Li Y, et al. Inotodiol protects PC12 cells against injury induced by oxygen and glucose deprivation/restoration through inhibiting oxidative stress and apoptosis[J]. Journal of Applied Biomedicine, 2018, 16 (2) : 126-132.|[4]Lee SH, et al., Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts. Biomed Pharmacother. 2022 Sep;153:113311.|[5]Liu Y, et al., Inotodiol, an antiasthmatic agent with efficacy and safety, preferentially impairs membrane-proximal signaling for mast cell activation. Int Immunopharmacol. 2023 Apr;117:109854.