DD1

DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].

Product Specifications

CAS Number

[187585-11-1]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Proteasome; Ribosomal S6 Kinase (RSK)

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dd1.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(N)=C(C2=CC=C(OC)C(N)=C2)OC3=CC=CC=C13

Molecular Formula

C16H14N2O3

Molecular Weight

282.29

Precautions

H301

References & Citations

[1]Marion Piedfer, et al. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochim Biophys Acta. 2013 Jun;1833 (6) :1316-28.