Jolkinolide A
Product Specifications
UNSPSC Description
Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells[1].
Target Antigen
Apoptosis; VEGFR
Type
Natural Products
Related Pathways
Apoptosis;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jolkinolide-a.html
Solubility
10 mM in DMSO
Smiles
CC1=C2[C@H]3O[C@]3([C@H]4C=C2OC1=O)CC[C@H]5[C@]4(CCCC5(C)C)C
Molecular Weight
314.42
References & Citations
[1]Shen L, et al. Jolkinolide A and Jolkinolide B Inhibit Proliferation of A549 Cells and Activity of Human Umbilical Vein Endothelial Cells. Med Sci Monit. 2017 Jan 14;23:223-237.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119767/Jolkinolide-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119767/
Clinical Information
No Development Reported
CAS Number
37905-07-0
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