MK771

MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome[1][2].

Product Specifications

CAS Number

[66537-55-1]

UNSPSC

12352005

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mk771.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@H](C(N1CSC[C@@H]1C(N)=O)=O)CC2=CNC=N2)[C@@H](N3)CCCC3=O

Molecular Formula

C16H22N6O4S

Molecular Weight

394.45

References & Citations

[1]McCreary AC, et al. The thyrotrophin-releasing hormone analogue MK771 induces tic-like behaviours: the effects of dopamine D1 and D2 receptor antagonists. Eur J Pharmacol. 1999 Mar 12;369 (1) :1-9.|[2]Bhargava HN, et al. Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome. Psychopharmacology (Berl) . 1985;87 (2) :141-6.