ATM Inhibitor-10
Product Specifications
UNSPSC Description
ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC50: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors[1].
Target Antigen
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-10.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N[C@H](C2=NN(C)C=C2)C)C3=CC(C4=CC=C(COC)N=C4)=C(F)C=C3N=C1)N
Molecular Weight
434.47
References & Citations
[1]Degorce SL, et al. Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase. J Med Chem. 2016 Jul 14;59(13):6281-92.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118911/ATM-Inhibitor-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118911/
Clinical Information
No Development Reported
CAS Number
1941214-06-7
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