FAK-IN-16
Product Specifications
UNSPSC Description
FAK-IN-16 (compound OXA-11) is an orally active, selective focal adhesion kinase (FAK) inhibitor with an IC50 of 1.2 pM. FAK-IN-16 inhibits FAK phosphorylation at pFAK[Y397] and pFAK[Y861]. FAK-IN-16 slows tumor growth and reduces tumor vascularity, invasion. FAK-IN-16 potentiates effects of Cisplatin (HY-17394) on tumor cell proliferation and apoptosis in vitro and anti-tumor actions in mice[1].
Target Antigen
FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-16.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(CP(OCC)(OCC)=O)=CC=C1NC2=NC=C(C(F)(F)F)C(NC3=CC=C([C@H]4CC[C@H](N5CCN(C)CC5)CC4)C(CN6C)=C3C6=O)=N2
Molecular Weight
759.80
References & Citations
[1]Ingrid Moen, et al. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015 Dec;32(8):799-817.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117836/FAK-IN-16-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117836/
Clinical Information
No Development Reported
CAS Number
1257994-15-2
Curated Selection
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