RB-6145
Product Specifications
UNSPSC Description
RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rb-6145.html
Solubility
10 mM in DMSO
Smiles
OC(CNCCBr)CN1C=CN=C1[N+]([O-])=O.Br
Molecular Weight
374.03
References & Citations
[1]S Cole, et al. Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. Int J Radiat Oncol Biol Phys. 1991 Jul;21(2):387-95.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117630/RB-6145-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117630/
Clinical Information
Phase 1
CAS Number
129448-97-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1417214 Inquire
Recombinant Schizosaccharomyces pombe Uncharacterized transcriptional regulatory protein C25B8.11 (SPAC25B8.11), partial
Ask
View Details MBS6359006-01 0.1 mL
TSC1, Phosphorylated (S312) (Tsc1, Kiaa0243, Hamartin, Tuberous sclerosis 1 protein homolog) (MaxLight 405)
Ask
View Details MBS6359006-02 5x 0.1 mL
TSC1, Phosphorylated (S312) (Tsc1, Kiaa0243, Hamartin, Tuberous sclerosis 1 protein homolog) (MaxLight 405)
Ask
View Details