RB-6145

RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].

Product Specifications

CAS Number

[129448-97-1]

UNSPSC

12352005

Target

Drug Intermediate

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rb-6145.html

Solubility

10 mM in DMSO

Smiles

OC(CNCCBr)CN1C=CN=C1[N+]([O-])=O.Br

Molecular Formula

C8H14Br2N4O3

Molecular Weight

374.03

References & Citations

[1]S Cole, et al. Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. Int J Radiat Oncol Biol Phys. 1991 Jul;21 (2) :387-95.