RB-6145
RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].
Product Specifications
CAS Number
[129448-97-1]
UNSPSC
12352005
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rb-6145.html
Solubility
10 mM in DMSO
Smiles
OC(CNCCBr)CN1C=CN=C1[N+]([O-])=O.Br
Molecular Formula
C8H14Br2N4O3
Molecular Weight
374.03
References & Citations
[1]S Cole, et al. Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. Int J Radiat Oncol Biol Phys. 1991 Jul;21 (2) :387-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
NBP2-90222H 0.1 mL
Rabbit Monoclonal Phosphoserine phosphatase Antibody (001) [HRP]
Ask
View Details 
GTR15132768 1 Vial
Lentiviral human PLB1 shRNA (UAS) - Lentiviral human PLB1 shRNA (UAS, RFP) (100)
Ask
View Details 224072-01 50 µL
MDK (Midkine, MK, Amphiregulin-Associated Protein, ARAP, Midgestation and kidney Protein, Neurite outgrowth-promoting Factor 2, Neurite outgrowth-promoting Protein, MDK, MK1, NEGF2) discontinued
Ask
View Details 224072-02 100 µL
MDK (Midkine, MK, Amphiregulin-Associated Protein, ARAP, Midgestation and kidney Protein, Neurite outgrowth-promoting Factor 2, Neurite outgrowth-promoting Protein, MDK, MK1, NEGF2) discontinued
Ask
View Details