Indolmycin

Indolmycin (TAK-083), an antibiotic, is a competitive inhibitor of prokaryotic tryptophanyl-tRNA synthetase (TrpS) . Indolmycin (TAK-083) possesses both anti-viral and anti-bacterial activity[1][2][3].

Product Specifications

CAS Number

[21200-24-8]

Product Name Alternative

TAK-083; PA-155A

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/indolmycin.html

Purity

99.90

Solubility

DMSO : 3 mg/mL (ultrasonic; warming)

Smiles

O=C1N=C(NC)O[C@H]1[C@@H](C2=CNC3=C2C=CC=C3)C

Molecular Formula

C14H15N3O2

Molecular Weight

257.29

References & Citations

[1]R G Werner, et al. Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase. Eur J Biochem. 1976 Sep;68 (1) :1-3.|[2]Julian G Hurdle, et al. Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. J Antimicrob Chemother. 2004 Aug;54 (2) :549-52.|[3]M R Harnden, et al. Thiazolinone analogues of indolmycin with antiviral and antibacterial activity. J Med Chem. 1978 Jan;21 (1) :82-7.