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GW 9578

Product Specifications

UNSPSC Description

GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].

Target Antigen

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gw-9578.html

Purity

99.6

Solubility

10 mM in DMSO

Smiles

CC(C)(SC1=CC=C(CCN(C(NC2=CC=C(F)C=C2F)=O)CCCCCCC)C=C1)C(O)=O

Molecular Weight

492.62

References & Citations

[1]P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8.|[2]Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139(1):163-71.|[3]Dallas C Jones, et al. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem. 2002 Mar 1;277(9):6838-45.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-117196/GW-9578-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-117196/GW-9578-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

247923-29-1

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