Nesvategrast
Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model[1].
Product Specifications
CAS Number
[1621332-91-9]
Product Name Alternative
SF0166
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nesvategrast.html
Solubility
10 mM in DMSO
Smiles
OC(C[C@@H](C1=CN=C(OC(F)F)C=C1)N2C(N(CCCC(N3)=CC=C4C3=NCCC4)CC2)=O)=O
Molecular Formula
C23H27F2N5O4
Molecular Weight
475.49
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
αvβ3; αvβ6; αvβ8
Available Sizes
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