LY243246

LY243246 ((6S) -DDATHF), the 6S diastereomer of DDATHF, is a potent competitive inhibitor of 5’-phosphoribosylglycinamide formyltransferase (GAR transformylase) . 6R- and 6S-diastereomers of DDATHF are remarkably similar and equiactive antimetabolites inhibitory to de novo purine synthesis[1].

Product Specifications

CAS Number

[106400-18-4]

Product Name Alternative

(6S) -DDATHF

UNSPSC

12352005

Target

Antifolate

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ly243246.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CC[C@H](CN2)CC3=C2NC(N)=NC3=O)C=C1)=O

Molecular Formula

C21H25N5O6

Molecular Weight

443.45

References & Citations

[1]Moran RG, et al. The 6S- and 6R-diastereomers of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis. J Biol Chem. 1989;264 (35) :21047-21051.|[2]Lehman NL. The stereospecific cytotoxic potency of (6R) and (6S) -5,10- dideazatetrahydrofolate correlates with cellular folylpolyglutamate synthetase levels. Biochimie. 1995;77 (4) :273-278.