ML299
Product Specifications
UNSPSC Description
ML299 is a selective allosteric modulator and a dual inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML299 decreases invasive migration in U87-MG glioblastoma cells[1].
Target Antigen
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml299.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)Br)N[C@H](CN2CCC3(N(CNC3=O)C4=CC=CC(F)=C4)CC2)C
Molecular Weight
489.38
References & Citations
[1]O'Reilly MC, et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem. 2013 Mar 28;56(6):2695-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116273/ML299-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116273/
Clinical Information
No Development Reported
CAS Number
1426916-00-8
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