AG 370

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM) . AG 370 displays weak inhibition of the EGF receptor[1].

Product Specifications

CAS Number

[134036-53-6]

UNSPSC

12352005

Target

PDGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ag-370.html

Purity

97.0

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

N#C/C(C#N)=C(N)/C(C#N)=C\C1=CC=C(NC=C2)C2=C1

Molecular Formula

C15H9N5

Molecular Weight

259.27

References & Citations

[1]M C Bryckaert, et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp Cell Res. 1992 Apr;199 (2) :255-61.