COX-1/2-IN-1

COX-1/2-IN-2 is a potent COX1/2 inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC50 values of 13.9 ± 3.21 µM and 6.4±0.74 µM, respectively[1].

Product Specifications

CAS Number

[2358849-47-3]

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-1-2-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=[N+]([O-])C(C2=CC=C(Cl)C=C2)=NC3=CC=C(Br)C=C13

Molecular Formula

C15H10BrClN2O

Molecular Weight

349.61

References & Citations

[1]Malose J. Mphahlele, et al. Synthesis, in vitro and in silico enzyme (COX-1/2 & LOX-5), free radical scavenging and cytotoxicity profiling of the 2,4-dicarbo substituted quinazoline 3-oxides. Medicinal Chemistry Research volume 31, pages146–164 (2022)