FF-10502

FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells[1].

Product Specifications

CAS Number

[184302-49-6]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ff-10502.html

Solubility

10 mM in DMSO

Smiles

O=C1N([C@@H]2S[C@H](CO)[C@@H](O)[C@@H]2F)C=CC(N)=N1

Molecular Formula

C9H12FN3O3S

Molecular Weight

261.27

References & Citations

[1]Shinji Mima, et al. FF-10502, an Antimetabolite with Novel Activity on Dormant Cells, Is Superior to Gemcitabine for Targeting Pancreatic Cancer Cells. J Pharmacol Exp Ther. 2018 Jul;366 (1) :125-135.