ERRγ inverse agonist 1
ERRγ Inverse Agonist 1 (Compound 12) is a potent, selective and orally bioavailable Estrogen-related Receptor grammar (ERRγ) inverse agonist, with an IC50 of 40 nM[1].
Product Specifications
CAS Number
[2316832-86-5]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ERR_gamma__Inverse_Agonist_1.html
Solubility
10 mM in H2O
Smiles
OC1=CC=CC(/C(C2=CC=C(N3CCN(C(C)C)CC3)C=C2)=C(C4=CC=CC=C4)\CCCO)=C1.[H]Cl.[H]Cl
Molecular Formula
C30H38Cl2N2O2
Molecular Weight
529.54
References & Citations
[1]Kim J, et al. Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J Med Chem. 2019 Feb 28;62 (4) :1837-1858.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERRβ; ERRγ; ERα
Curated Selection
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