Uridine 5'-diphosphate-13C9,15N2 (dilithium)

Uridine 5'-diphosphate-13C9,15N2 dilithium is 13C and 15N-labeled Uridine 5'-diphosphate (HY-113359) . Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.

Product Specifications

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds; P2Y Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/uridine-5-diphosphate-13c9-15n2-dilithium.html

Concentration

100 mM in 23.42 μL Tris HCl/H2O buffer pH=7.5

Purity

99.5

Solubility

10 mM in DMSO

Smiles

O[13C@@H]1[13C@H](O)[13C@@H]([13CH2]OP(OP(O[Li])(O[Li])=O)(O)=O)O[13C@H]1[15N]2[13C]([15NH][13C]([13CH]=[13CH]2)=O)=O

Molecular Formula

13C9H12Li2 15N2O12P2

Molecular Weight

426.95

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Ashleigh S Paparella, et al. Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State. ACS Chem Biol. 2022 Sep 16;17 (9) :2507-2518.|[3]Besada P, et al. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49 (18) :5532-43.