2-Hydroxyestrone-d4

2-Hydroxyestrone-d4 is the deuterium labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

Product Specifications

CAS Number

[81586-97-2]

Product Name Alternative

Catecholestrone-d4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Endocrinology

Purity

97.94

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12[C@](CC([2H])([2H])C2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=C([2H])C(O)=C(O)C([2H])=C4CC3

Molecular Formula

C18H18D4O3

Molecular Weight

290.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]H L Bradlow, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.|[3]J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259 (8) :4840-5.|[4]M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13 (12) :1208-13.