AT-121

AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].

Product Specifications

CAS Number

[2099681-31-7]

UNSPSC

12352005

Hazard Statement

H302-H310-H315-H319-H331-H351-H361-H372

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/at-121.html

Concentration

2.16 mM * 100 μL in Chloroform

Purity

99.73

Solubility

10 mM in DMSO

Smiles

O=S(N)(NCCN1CC2=C(C=CC=C2)C3(CCN([C@H]4CC[C@@H](C(C)C)CC4)CC3)C1=O)=O

Molecular Formula

C24H38N4O3S

Molecular Weight

462.65

Precautions

P260-P261-P262-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ding H, Kiguchi N, Yasuda D, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10 (456) :eaar3483. doi:10.1126/scitranslmed.aar3483