PC-766B

PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na+, K+-ATPase[1][2].

Product Specifications

CAS Number

[108375-77-5]

Product Name Alternative

Antibiotic PC-766B

UNSPSC

12352005

Target

Antibiotic; Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/pc-766b.html

Solubility

10 mM in DMSO

Smiles

O=C1O[C@@H]([C@H](/C=C/C=C(C[C@@H]([C@@H]([C@@H](/C=C(/C=C1\OC)C)C)O)C)\C)OC)[C@H]([C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C=C/C)C)O[C@H]3C[C@@H](O)[C@H](O)[C@H](O3)C)O)O)C

Molecular Formula

C43H68O12

Molecular Weight

776.99

References & Citations

[1]Kumagai K, et, al. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. I. Taxonomy, fermentation and biological activity. J Antibiot (Tokyo) . 1993 Jun;46 (6) :972-8.|[2]Kumagai K, et, al. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. II. Isolation, physico-chemical properties and structure elucidation. J Antibiot (Tokyo) . 1993 Jul;46 (7) :1139-44.