ABT-702 (hydrochloride)
Product Specifications
UNSPSC Description
ABT-702 hydrochloride is a potent inhibitor of adenosine kinase with an IC50 of 1.7 nM[1][2].
Target Antigen
Adenosine Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/abt-702-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
NC1=C(C(C2=CC=CC(Br)=C2)=CC(C3=CC=C(N4CCOCC4)N=C3)=N5)C5=NC=N1.Cl
Molecular Weight
499.79
References & Citations
[1]Jarvis MF, et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse. J Pharmacol Exp Ther. 2000 Dec;295(3):1156-64.|[2]Parkinson FE, et al. The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study. J Neuroimaging. 2016 Jul;26(4):403-5.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112482A/ABT-702-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112482A/
Clinical Information
No Development Reported
CAS Number
2624336-92-9
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