ST638

ST638 is a potent tyrosine kinase inhibitor (IC50=370 nM) . ST638 also targets the CSF-1 receptor and inhibits PGE2 production[1][2].

Product Specifications

CAS Number

[107761-24-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/st638.html

Solubility

10 mM in DMSO

Smiles

O=C(N)/C(C#N)=C/C1=CC(CSC2=CC=CC=C2)=C(O)C(OCC)=C1

Molecular Formula

C19H18N2O3S

Molecular Weight

354.42

Precautions

P264-P270-P330-P501

References & Citations

[1]Fuortes M, et al. Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J Cell Biol. 1993 Feb;120 (3) :777-84.|[2]Puri J, et al. Selective inhibition of PGE2 production in cells transfected with c-fms encoded CSF-1 receptor genes by the tyrosine kinase inhibitor, ST638. Agents Actions. 1991 Jul;33 (3-4) :314-7.