GSK8175

GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV) . GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons[1].

Product Specifications

CAS Number

[1423007-82-2]

Product Name Alternative

GSK2878175

UNSPSC

12352005

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gsk8175.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C(C=C2)=CC=C2F)OC3=CC(N(C4=CC(Cl)=C5C(COB5O)=C4)[S](C)(=O)=O)=C(C6CC6)C=C13)NC

Molecular Formula

C27H23BClFN2O6S

Molecular Weight

568.81

References & Citations

[1]Chong PY, et al. Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. J Med Chem. 2019;62 (7) :3254-3267.