6'-GNTI (dihydrochloride)
Product Specifications
UNSPSC Description
6'-GNTI dihydrochloride, a κ-opioid receptor (KOR) agonist, displays bias toward the activation of G protein-mediated signaling over β-arrestin2 recruitment. 6'-GNTI 6'-GNTI dihydrochloride only activates the Akt pathway in striatal neurons[1].
Target Antigen
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6-gnti-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O[C@]12[C@](C3=C(C=C4)C[C@H]2N5CC6CC6)(CC5)[C@](OC3=C4O)([H])C(NC7=CC(NC(N)=N)=CC=C87)=C8C1.Cl.Cl
Molecular Weight
544.47
References & Citations
[1]Schmid CL, et al. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons. J Biol Chem. 2013;288(31):22387-22398.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110302/6-GNTI-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110302/
Clinical Information
No Development Reported
CAS Number
2410327-94-3
Curated Selection
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