ONO-8130

ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research[1].

Product Specifications

CAS Number

[459841-96-4]

UNSPSC

12352005

Target

PERK; Prostaglandin Receptor

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ono-8130.html

Solubility

10 mM in DMSO

Smiles

O=[S](N(C(C=C(CCC1)C1=C2)=C2OCC(C=C3)=CC=C3C(O)=O)CC(C)C)(C4=NC(C)=CS4)=O

Molecular Formula

C25H28N2O5S2

Molecular Weight

500.63

References & Citations

[1]Miki T, et al. ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain. 2011 Jun;152 (6) :1373-1381.