TFC 007

TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC50 value of 83 nM) . TFC-007 can be used for composing H-PGDS degradation inducer PROTAC (H-PGDS) -1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon) [1].

Product Specifications

CAS Number

[927878-49-7]

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC; PGE synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tfc-007.html

Purity

98.01

Solubility

DMSO : 1 mg/mL (ultrasonic; warming)

Smiles

O=C(N1CCOCC1)C2CCN(C3=CC=C(NC(C4=CN=C(OC5=CC=CC=C5)N=C4)=O)C=C3)CC2

Molecular Formula

C27H29N5O4

Molecular Weight

487.55

References & Citations

[1]Hidetomo Yokoo, et al. Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett. 2021 Jan 14;12 (2) :236-241.