Mesdopetam

Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2].

Product Specifications

CAS Number

[1403894-72-3]

Product Name Alternative

IRL790

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mesdopetam.html

Solubility

10 mM in DMSO

Smiles

CCCNCCOC1=CC(S(=O)(C)=O)=CC(F)=C1

Molecular Formula

C12H18FNO3S

Molecular Weight

275.34

References & Citations

[1]Waters S, et al. Preclinical Pharmacology of [2- (3-Fluoro-5-Methanesulfonyl-phenoxy) Ethyl] (Propyl) amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. 2020;374 (1) :113-125. |[2]Becanovic K, et al. Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission. J Pharmacol Exp Ther. 2020;374 (1) :126-133.