Pecavaptan

Pecavaptan, a chemical probe, is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively) . Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema[1].

Product Specifications

CAS Number

[1914998-56-3]

Product Name Alternative

BAY 1753011

UNSPSC

12352005

Target

Vasopressin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pecavaptan.html

Solubility

10 mM in DMSO

Smiles

O[C@H](C(F)(F)F)CN1C(C2=CC=C(Cl)C=C2)=NN(CC3=NN(C4=CC(Cl)=CC=C4)C([C@@H](O)C)=N3)C1=O

Molecular Formula

C22H19Cl2F3N6O3

Molecular Weight

543.33

References & Citations

[1]Mondritzki T, et al. Cardiac output improvement by pecavaptan: a novel dual-acting vasopressin V1a/V2 receptor antagonist in experimental heart failure. Eur J Heart Fail. 2021 May;23 (5) :743-750.