Mecasermin

Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I) . Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies[1].

Product Specifications

CAS Number

[68562-41-4]

Product Name Alternative

Human IGF-I; FK 780

UNSPSC

12352209

Target

IGF-1R

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mecasermin.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CO)=O)=O)=O)NC4=O)C(NCC(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(N6[C@@H](CCC6)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N7[C@@H](CCC7)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC8=O)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N%12[C@@H](CCC%12)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CC%13=CC=C(C=C%13)O)C(NCC(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N%14[C@@H](CCC%14)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(N[C@H]8CC%15=CC=C(C=C%15)O)=O)=O)=O)=O)=O)=O)=O)=O)NC3=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C331H512N94O101S7

Molecular Weight

7645.68

References & Citations

[1]Arlan L Rosenbloom. Mecasermin (recombinant human insulin-like growth factor I) . Adv Ther. 2009 Jan;26 (1) :40-54.|[2]Jorge Castro, et al. Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome. Proc Natl Acad Sci U S A. 2014 Jul 8;111 (27) :9941-6.