AZ 11645373
Product Specifications
UNSPSC Description
AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors，AZ11645373 inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells , with an IC50 value of 90 nM[1].
Target Antigen
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/az-11645373.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C(COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC4=CC=NC=C4)SCC1=O
Molecular Weight
463.51
References & Citations
[1]Stokes L, et al. Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373. Br J Pharmacol. 2006 Dec;149(7):880-7.
Shipping Conditions
Room temperature
Storage Conditions
Store at room temperature 3 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108670/AZ-11645373-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108670/
Clinical Information
No Development Reported
CAS Number
227088-94-0
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