CGS35066
CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1) . CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively[1].
Product Specifications
CAS Number
[261619-50-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endothelin-Converting Enzyme (ECE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cgs35066.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O)CN[C@H](C(O)=O)CC1=CC=C(C2=CC=CC=C2O3)C3=C1
Molecular Formula
C16H16NO6P
Molecular Weight
349.28
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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