JNJ-5207787

JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors[1].

Product Specifications

CAS Number

[683746-68-1]

UNSPSC

12352005

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jnj-5207787.html

Purity

98.00

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

N#CC1=CC=CC(/C=C/C(N(C2CCN(CCC3CCCC3)CC2)C4=CC=C(CCN5C(C)=O)C5=C4)=O)=C1

Molecular Formula

C32H38N4O2

Molecular Weight

510.67

References & Citations

[1]Bonaventure P, et al. Characterization of N- (1-Acetyl-2,3-dihydro-1H-indol-6-yl) -3- (3-cyano-phenyl) -N-[1- (2-cyclopentyl-ethyl) -piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide YY2 receptor. J Pharmacol Exp Ther. 2004 Mar;308 (3) :1130-7.