NS3763

NS3763 is a selective and noncompetitive GLUK5 receptor antagonist with an IC50 of 1.6 µM. NS3763 does not show significant antagonistic properties on GLUK6, AMPA or NMDA receptors[1].

Product Specifications

CAS Number

[70553-45-6]

UNSPSC

12352005

Hazard Statement

H315-H319-H335-H410

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ns3763.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(NC(C2=CC=CC=C2)=O)C=C(NC(C3=CC=CC=C3)=O)C(C(O)=O)=C1)O

Molecular Formula

C22H16N2O6

Molecular Weight

404.37

Precautions

P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P391-P403+P233-P405-P501

References & Citations

[1]Jeppe K Christensen, et al. In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J Pharmacol Exp Ther. 2004 Jun;309 (3) :1003-10.