Macbecin
Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].
Product Specifications
CAS Number
[73341-72-7]
Product Name Alternative
Macbecin I; NSC 330499
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/macbecin.html
Solubility
10 mM in DMSO
Smiles
O=C(C(NC(/C(C)=C/C=C/[C@H](C)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H](OC)[C@@H](OC)C[C@@H]1C)=O)=C2)C([C@]1([H])OC)=CC2=O
Molecular Formula
C30H42N2O8
Molecular Weight
558.66
References & Citations
[1]Martin CJ, et al. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 2008 May 8;51 (9) :2853-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
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