KDM2/7-IN-1

KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively) . KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1].

Product Specifications

CAS Number

[1453071-47-0]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kdm2-7-in-1.html

Purity

99.9

Solubility

DMSO : 30 mg/mL (ultrasonic)

Smiles

OC(CCN(O)C(CCCCCCCCC1CC1)=O)=O

Molecular Formula

C15H27NO4

Molecular Weight

285.38

Precautions

H315, H319

References & Citations

[1]Suzuki T, et al. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26;56 (18) :7222-31.