AR-A 2

AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.

Product Specifications

CAS Number

[220051-79-6]

Product Name Alternative

AR-A 000002

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AR-A_2.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(N2CCN(C)CC2)C3=C1CC[C@@H](NC(C4=CC=C(N5CCOCC5)C=C4)=O)C3

Molecular Formula

C27H36N4O2

Molecular Weight

448.60

References & Citations

[1]Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine (1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499 (1-2) :67-75.