Litoxetine
Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT3 receptor antagonist with a Ki of 85 nM for cerebral 5-HT3 receptors. Litoxetine is an antidepressant and has antiemetic properties[1].
Product Specifications
CAS Number
[86811-09-8]
Product Name Alternative
SL 81.0385
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/litoxetine.html
Solubility
10 mM in DMSO
Smiles
C1(COC2CCNCC2)=CC3=C(C=CC=C3)C=C1
Molecular Formula
C16H19NO
Molecular Weight
241.33
References & Citations
[1]I Angel, et al. Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Eur J Pharmacol. 1993 Mar 2;232 (2-3) :139-45.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-106807/Litoxetine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106807/
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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