PF-03049423 (free base)
Product Specifications
UNSPSC Description
PF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-03049423-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C1C(N2CCN(CC2)CCO)=NC3=C(N1CCOCCC)C=C(C4=CC=C(OC)N=C4)N=C3
Molecular Weight
468.55
References & Citations
[1]Menniti FS, et al. Phosphodiesterase 5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism. J Pharmacol Exp Ther. 2009 Dec;331(3):842-50.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10679/PF-03049423-free-base-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10679/
Clinical Information
Phase 2
CAS Number
954138-07-9
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